To cite this article: Chin, S. F. et al. (2016). Fabrication of cellulose aerogel from sugarcane bagasse as drug delivery carriers. J. Phys. Sci., 27(3), 159–168, http://dx.doi.org/10.21315/jps2016.27.3.10
Currently most of the aerogel-based drug delivery carriers are made from non-biodegradable materials, such as silica. In this study, highly porous cellulose aerogels with Brunauer-Emmett-Teller (BET) surface areas that varied between 22 m2 g–1 and 525 m2 g–1 were prepared from a sugarcane bagasse cellulose solution of various concentrations. The potential utility of cellulose aerogels as controlled release carriers was evaluated by loading methylene blue (MB) as a model hydrophilic drug. The MB loading capacity and release kinetic profiles of cellulose aerogels were observed to be substantially influenced by their BET surface areas. Under optimum conditions, a maximum loading capacity of 6.4 mg MB mg–1 cellulose aerogel was achieved with sustained release of MB from cellulose aerogels at physiological pH over a period
of 23 h.