To cite this article: Adam, F. et al. (2016). The synthesis and characterisation of 2-methyl-N-((4-methylpyridine-2-yl)carbamothiol)benzamide: Its preparation with antibacterial study. J. Phys. Sci., 27(2), 83–101, http://dx.doi.org/10.21315/jps2016.27.2.7
ABSTRACT
The compound, 2-methyl-N-((4-methylpyridin-2-yl)carbamothioyl)benzamide was derived from ortho-toluylchloride and 2-amino-4-picoline. It was fully crystallised and characterised on the basis of elemental analysis, X-ray crystallography and spectroscopic techniques namely infra-red, Uv-Vis and nuclear magnetic resonance. The melting point was in the range of 164.9°C–165.8°C. The Fourier transform infrared (FTIR) analysis shows the following vibrational frequencies for ⱱ(N-H), ⱱ(C=O), ⱱ(C-N) and ⱱ(C=S) at 3237 cm–1, 1683 cm–1, 1329 cm–1 and 1154 cm–1 respectively. 1H NMR results showed chemical shifts at 9.140 ppm and 12.983 ppm for the two N-H protons. Single crystal X-ray diffraction studies on the compound showed it to be a rigid molecule due to the presence of internal hydrogen bonding. The compound shows antibacterial activity towards gram positive and gram negative bacteria.
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