Synthesis, Characterisation and Vasolidation Properties of Indanone-based Chalcones

To cite this article: Mohd Sabri, M. S., Oo, C. W. & Yam, M. F. (2018). Synthesis,
characterisation and vasolidation properties of indanone-based chalcones. J. Phys. Sci., 29(Supp. 1), 99–106,


Six indanone-based chalcones were successfully synthesised from 1-indanone and 4-benzaldehyde derivatives via Claisen-Schmidt condensation reaction. The synthesised indanone-based chalcones were characterised by CHN elemental analysis, FTIR spectroscopy and NMR spectroscopy to determine their structures. Vasodilation studies indicated compounds 1b1 and 1-OH showed good vasodilation properties with Rmax value of 38.34 ± 8.90% and 96.68 ±14.77%, respectively. Compound with hydroxyl group shows better effect to the relaxation of the aortic rings.


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