Toxicity of Zinc Oxide Nanoparticles Prepared with Plasma Jet for in Vitro and in Vivo Study


This study shows how zinc oxide nanoparticles (ZnO NPs) affect the blood component of adult male rats utilising a safe, simple and inexpensive plasma jet production approach for varying exposure periods. The ZnO NPs were described as follows: the X-ray diffraction (XRD) pattern showed that in the UV-visible spectrum of the peak region at 291 nm to 302 nm, the strong intensity peaks indicated the crystalline nature of the ZnO NPs. A field emission scanning electron microscopy (FE-SEM) was used to look at the morphology of the ZnO NPs. The diameters of the spherical particles ranged from 30 nm to 96 nm. Two sets of ZnO NP dosages are used to investigate the impact of ZnO NPs on component blood. White blood cells (WBC), red blood cells (RBC), haemoglobin (HB) and platelets (Plt) components in the blood increase when ZnO NPs dosages rise. The cytotoxicity of the rat embryonic fibroblast (REF) normal cell line is calculated concurrently and the highest cytotoxicity equals 9% at 100% ZnO NPs concentration. These results suggest that a variety of blood component-affecting disorders may be treated using the ZnO NPs receptor.